Fred Hutchinson Cancer Center is an independent, nonprofit, unified adult cancer care and research center that is clinically integrated with UW Medicine, a world leader in clinical care, research and learning. The first National Cancer Institute-designated cancer center in the Pacific Northwest, Fred Hutch’s global leadership in bone marrow transplantation, HIV/AIDS prevention, immunotherapy, and COVID-19 vaccines has confirmed our reputation as one of the world’s leading cancer, infectious disease and biomedical research centers. Based in Seattle, Fred Hutch operates eight clinical care sites that provide medical oncology, infusion, radiation, proton therapy, and related services, and network affiliations with hospitals in five states. Together, our fully integrated research and clinical care teams seek to discover new cures to the world’s deadliest diseases and make life beyond cancer a reality.
At Fred Hutch, we believe that the innovation, collaboration, and rigor that result from diversity and inclusion are critical to our mission of eliminating cancer and related diseases. We seek employees who bring different and innovative ways of seeing the world and solving problems. Fred Hutch is in pursuit of becoming an antiracist organization. We are committed to ensuring that all candidates hired share our commitment to diversity, antiracism, and inclusion.
The Srivastava lab in the Human Biology Division at Fred Hutchinson Cancer Research Center is recruiting a Post-Doctoral Fellow with expertise in immunology to lead a project developing strategies to counter CAR-T cell exhaustion in solid tumors. The Srivastava lab focuses on using mouse models of human cancer to define the mechanisms limiting the activity of CAR- and TCR-engineered T cells in solid tumors and to develop strategies to overcome these barriers that can be readily translated to the clinic.
The candidate would lead a project centered on understanding how dysfunction develops in CAR-T cells in vivo, performing and validating genetic screens to identify regulators of CAR function, and defining inhibitory mechanisms in the tumor microenvironment that could be targeted in combination to durably enhance CAR-T cell activity. The work would involve using methods of molecular biology (cloning, CRISPR/Cas9 gene editing), extensive in vivo work with transplantable and genetically engineered mouse models, multi-parameter flow cytometry, and single-cell genomics.
To be considered for this role, please include a cover letter and contact information for 2-3 professional or academic references.
- PhD in immunology, tumor biology, or related field
- Experience or interest in working with complex mouse tumor models
- Eligibility and desire to apply for future fellowships
- Evidence of productivity, creativity, and strong analytical and interpersonal skills
- The candidate should be enthusiastic about this research area, goal-oriented, a self-starter, and be able to work independently in a team environment
- Expertise in multiparameter flow cytometry (10+ colors)
- Experience working with mouse models and familiarity with various handling techniques (e.g. tail vein, retro-orbital, subcutaneous injections)
- Experience with CRISPR/Cas9 gene-editing
- Experience in next generation sequencing data analysis, particularly for single cell RNAseq, ATACseq, and/or CUT&Tag
- Excellent knowledge of fundamental immunology
- Strong analytical, writing, communication, and problem-solving skills are desired.
Fred Hutch has a mandatory COVID-19 vaccine requirement, with exceptions only for approved medical or religious accommodations.
As a condition of employment, newly hired employees must provide proof of vaccination or initiate the accommodations process before their first day of employment.
A statement describing your commitment and contributions toward greater diversity, equity, inclusion, and antiracism in your career or that will be made through your work at Fred Hutch is requested of all finalists.
Our Commitment to Diversity
We are proud to be an Equal Employment Opportunity (EEO) and Vietnam Era Veterans Readjustment Assistance Act (VEVRAA) Employer. We are committed to cultivating a workplace in which diverse perspectives and experiences are welcomed and respected. We do not discriminate on the basis of race, color, religion, creed, ancestry, national origin, sex, age, disability (physical or mental), marital or veteran status, genetic information, sexual orientation, gender identity, political ideology, or membership in any other legally protected class. We are an Affirmative Action employer. We encourage individuals with diverse backgrounds to apply and desire priority referrals of protected veterans. If due to a disability you need assistance/and or a reasonable accommodation during the application or recruiting process, please send a request to our Employee Services Center at email@example.com or by calling 206-667-4700.